Sv: Lavkarbo og kreft
Här kommer ett intressant abstract:
"J Am Coll Nutr. 1995 Apr;14(2):202-8. Effects of a ketogenic diet on
tumor metabolism and nutritional status in pediatric oncology
patients: two case reports.
Nebeling LC, Miraldi F, Shurin SB, Lerner E.
Nutrition Department, Case Western Reserve University, School of
Medicine, Cleveland, Ohio, USA.
OBJECTIVE: Establish dietary-induced ketosis in pediatric oncology
patients to determine if a ketogenic state would decrease glucose
availability to certain tumors, thereby potentially impairing tumor
metabolism without adversely affecting the patient's overall
nutritional status. DESIGN: Case report. SETTING: University
Hospitals of Cleveland. SUBJECTS: Two female pediatric patients with
advanced stage malignant Astrocytoma tumors. INTERVENTIONS: Patients
were followed as outpatients for 8 weeks. Ketosis was maintained by
consuming a 60% medium chain triglyceride oil-based diet. MAIN
OUTCOME MEASURES: Tumor glucose metabolism was assessed by Positron
Emission Tomography (PET), comparing [Fluorine-18] 2-deoxy-2-fluoro-
D-glucose (FDG) uptake at the tumor site before and following the
trial period. RESULTS: Within 7 days of initiating the ketogenic
diet, blood glucose levels declined to low-normal levels and blood
ketones were elevated twenty to thirty fold. Results of PET scans
indicated a 21.8% average decrease in glucose uptake at the tumor
site in both subjects. One patient exhibited significant clinical
improvements in mood and new skill development during the study. She
continued the ketogenic diet for an additional twelve months,
remaining free of disease progression. CONCLUSION: While this diet
does not replace conventional antineoplastic treatments, these
preliminary results suggest a potential for clinical application
which merits further research."
Sten Sture
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