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Taken collectively, these data provide evidence for the idea that there is biological (active) control of body weight and also weight stability (and thus a set point at a healthy steady state) in response to eating healthy chow diets. By contrast, this regulation is lost or camouflaged by Western diets, suggesting that the failure of biological control is due mainly to external factors. In this situation, the set point is replaced by various settling points that are influenced by energy and macronutrient intake in order for the body to reach a zero balance of energy and macronutrients and thus a new and possibly unhealthy steady state.