Vis enkelt innlegg
Gammel 14-06-22, 11:01   #1
StineK
Seniormedlem
 
StineK sin avatar
 
Medlem siden: Dec 2007
Hvor: Utenfor Bergen
Innlegg: 15.183
StineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastiskStineK er bare helt fantastisk

Keto gjør musklene motstandsdyktige

Forskere ved Stanford:



https://www.cell.com/cell-metabolism...131(22)00182-6


Short-term fasting is beneficial for the regeneration of multiple tissue types. However, the effects of fasting on muscle regeneration are largely unknown.



Here, we report that fasting slows muscle repair both immediately after the conclusion of fasting as well as after multiple days of refeeding. We show that ketosis, either endogenously produced during fasting or a ketogenic diet or exogenously administered, promotes a deep quiescent state in muscle stem cells (MuSCs).



Although deep quiescent MuSCs are less poised to activate, slowing muscle regeneration, they have markedly improved survival when facing sources of cellular stress.



Furthermore, we show that ketone bodies, specifically β-hydroxybutyrate, directly promote MuSC deep quiescence via a nonmetabolic mechanism. We show that β-hydroxybutyrate functions as an HDAC inhibitor within MuSCs, leading to acetylation and activation of an HDAC1 target protein p53. Finally, we demonstrate that p53 activation contributes to the deep quiescence and enhanced resilience observed during fasting.

__________________




Det er alltid hyggelig med besøk i Journalen min - StineK uten sukker, takk!
StineK er avlogget   Min kostholdsfilosofi: Lavkarbo Svar med sitat